Dynamical systems theory of cellular reprogramming

In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of a few genes, resulting in regaining pluripotency, the potential for differentiation.Considering the interplay between oscillatory Hoodies/Fleece gene expression and slower epigenetic modifications, such reprogramming is perceived as an unintuitive, global attraction to the unstable manifold of a saddle, which represents pluripotency.The universality Adapter of this scheme is confirmed by the repressilator model and by gene regulatory networks that are randomly generated and extracted from embryonic stem cells.